Frequent evolutionary birth and death events have created a large quantity of biologically important, lineage‐specific DNA within mammalian genomes. The birth and death of DNA sequences is so frequent that the total number of these insertions and deletions in the human population remains unknown, although there are differences between these groups, e.g. transposable elements contribute predominantly to sequence insertion. Functional turnover – where the activity of a locus is specific to one lineage, but the underlying DNA remains conserved – can (...) also drive birth and death. However, this does not appear to be a major driver of divergent transcriptional regulation. Both sequence and functional turnover have contributed to the birth and death of thousands of functional promoters in the human and mouse genomes. These findings reveal the pervasive nature of evolutionary birth and death and suggest that lineage‐specific regions may play an important but previously underappreciated role in human biology and disease. (shrink)

In his case report, A Logic in Madness, Aaron Hauptman details the case of Mr. A, an intelligent college student with Asperger’s syndrome, who became severely depressed subsequent to what he perceived as a rejection by what he viewed as “the love of his life.” Dr. Hauptman describes Mr. A as suicidal and as suffering from all the hallmarks of a major depression. At the urging of his family, he presents himself to a psychiatric inpatient unit and agrees to a (...) voluntary hospitalization. However, he refuses pharmacological treatment or electroconvulsive therapy, both of which his clinicians are considering given the severity of his case. Dr. Hauptman describes the young man’s response... (shrink)

In domains with multiple competing goals, people face a basic challenge: How to make their strategy use flexible enough to deal with shifting circumstances without losing track of their overall objectives. This article examines how young children meet this challenge in one such domain, tic‐tac‐toe. Experiment 1 provides an overviews of development in the area; it indicates that children's tic‐tac‐toe strategies are rule based and that new rules are added one at a time. Experiment 2 demonstrates that even (...) class='Hi'>young children flexibly tailor their strategy use to meet shifting circumstances. Experiment 3 indicates that these adaptations are accomplished through a process of goal‐based resource allocation, whereby children focus their cognitive resources on applying rules most consistent with their current primary goal. A computer simulation specifies how this process works and demonstrates its sufficiency for producing behavior much like that of the children. The findings are discussed as part of a broader framework of mechanisms for generating problem‐solving approaches. (shrink)

The Second Vatican Council has a special significance in Latin America. This is especially true due to the influence of the document Gaudium et Spes. This took place at the Medellín Conference when Bishop Marcus Gregorio McGrath, C.S.C., pointed to this influence through his keynote address “The Signs of the Times.” He was prepared for this moment through his earlier theological training in Europe and his pastoral missions, especially in Chile and Panama. It was his earlier practice of Catholic Action (...) among young lay persons that led him into the “bridge theology” that was to be promoted further by Pope Francis. (shrink)

This short history of Pembroke College, Cambridge appeared in 1936, during a particularly successful period for the college in terms of both academic and sporting achievements. Pembroke was founded in 1347, when Edward III granted Marie de St Pol, widow of the Earl of Pembroke, a licence for the foundation of a new educational establishment in the young University of Cambridge. The college flourished, and from the mid-nineteenth century expanded greatly. The author of this book, which is still regarded (...) as the 'official history of Pembroke College', was a leading authority on the college's history. However, he died before the manuscript could be completed, and the final part was written as a postscript by S. C. Roberts, a former Master of the college. The book has delightful illustrations and a thorough index of the influential scholars, former students and benefactors connected with the college over the centuries. (shrink)

It is not too great an exaggeration to claim that On the Origin of Species was, along with Das Kapital, one of the two most significant works in the intellectual history of the nineteenth century. As George Henry Lewes wrote in 1868, ‘No work of our time has been so general in its influence’. However, the very generality of the influence of Darwin’s work provides the chief problem for the intellectual historian. Most books and articles on the subject assert the (...) influence but remain very imprecise about its nature. It is very difficult indeed to assess what it was about the Darwinian theory which was so influential and how its influence was felt. This problem in Victorian intellectual history intersects with a related one in the history of science. There has been a tendency on the part of historians of science to isolate Darwin in two related ways. The first is to single him out from the mainstream of nineteenth-century naturalism in Britain and allow ‘Darwinism’ to stand duty for the wider movement of which it was in fact but a part. The second is the tendency to single out his evolutionary theory and to demarcate it sharply from those of his predecessors and contemporaries. According to this interpretation Darwin stood alone as a real, empirical scientist and provided the first genuinely scientific hypothesis for the process by which evolution might have occurred. The theories of the other main evolutionists—Erasmus Darwin, Lamarck, Chambers, Spencer, and Wallace—were more or less besmirched by ideological, anthropomorphic, or other ‘non-scientific’ factors or by the uses to which they were put by their authors. Charles Darwin is thus made to stand out as a figure of comparatively unalloyed scientific status and is treated in relative isolation from the social and intellectual context in which he worked and into which his theory was received. (shrink)

It is not too great an exaggeration to claim that On the Origin of Species was, along with Das Kapital, one of the two most significant works in the intellectual history of the nineteenth century. As George Henry Lewes wrote in 1868, ‘No work of our time has been so general in its influence’. However, the very generality of the influence of Darwin’s work provides the chief problem for the intellectual historian. Most books and articles on the subject assert the (...) influence but remain very imprecise about its nature. It is very difficult indeed to assess what it was about the Darwinian theory which was so influential and how its influence was felt. This problem in Victorian intellectual history intersects with a related one in the history of science. There has been a tendency on the part of historians of science to isolate Darwin in two related ways. The first is to single him out from the mainstream of nineteenth-century naturalism in Britain and allow ‘Darwinism’ to stand duty for the wider movement of which it was in fact but a part. The second is the tendency to single out his evolutionary theory and to demarcate it sharply from those of his predecessors and contemporaries. According to this interpretation Darwin stood alone as a real, empirical scientist and provided the first genuinely scientific hypothesis for the process by which evolution might have occurred. The theories of the other main evolutionists—Erasmus Darwin, Lamarck, Chambers, Spencer, and Wallace—were more or less besmirched by ideological, anthropomorphic, or other ‘non-scientific’ factors or by the uses to which they were put by their authors. Charles Darwin is thus made to stand out as a figure of comparatively unalloyed scientific status and is treated in relative isolation from the social and intellectual context in which he worked and into which his theory was received. (shrink)

An application of Young's Habermasian critical theory of education to classroom communication problems of teachers in schools, with a special focus on the question/answer cycle and its educational role. The book uses classroom transcripts extensively in the analysis.

Contrary to the received opinion that Pablo Picasso conceived of Guernica only after learning of the bombing of the Basque town on 26 April 1937, and in direct response to it, in this article we demonstrate that the mural was visualized much earlier, as part of Picasso’s larger artistic and intellectual response to war. In February 1937 Picasso met with José Luis Sert, the architect of the Spanish Pavilion planned for the Paris World Fair that was to open in June. (...) That he was so quickly able to provide the architect with the exact dimensions of the mural suggests that he had already conceived a vision and plan for the painting that would only later be known as Guernica—a vision that saw him less preoccupied with iconographical minutiae than with visual problem-solving around a general theme: the types and consequences of political violence in Spain and wars past, present, and future. In searching for inspiration, Picasso paid homage to three other artists whose works reflected different aspects of this theme: Francisco Goya, Robert Capa, and David Seymour. The whole mural was painted in black and white because Picasso was certain that Guernica would be seen as a work of photojournalism, which form of journalism had only recently started to be transmitted by wire and radio services. Lastly, Picasso was confident that his painting would eventually be installed in the Prado Museum and be compared to both of Goya’s paintings, The Second of May 1808 (1814) and The Third of May 1808 (1814). To place himself as pre-eminent, Picasso made Guernica larger than either of Goya’s paintings by subsuming the former into a completely original compositional overlay. (shrink)

Robert Maxwell Young's first book Mind, Brain and Adaptation in the Nineteenth Century, written from 1960 to 1965, still merits reading as a study of the naturalization of mind and its relation to social thought in Victorian Britain. I examine the book from two perspectives that give the volume its unique character: first, Young's interest in psychology, which he considered should be used to inform humane professional practices and be the basis of social reform; second, new approaches (...) to the history of scientific ideas. I trace Young's intellectual interests to the Yale Philosophy Department, the Cambridge Department of Experimental Psychology and a new history and philosophy of science community. Although Young changed his political outlook and historiography radically after 1965, he always remained faithful to ideas about thought and practice described in Mind, Brain. (shrink)

I want to begin by saying that the terms of reference of this series of lectures grated on me, in particular, the word ‘power’. One thing it conjured up was the criticism made by people who say we use our power over our patients to brainwash them, that the psychotherapeutic relationship is inescapably authoritarian, domineering, coercive. This was widely said in the sixties by leftist and feminists and others who sought a therapeutic relationship that was more equal, co-counselling, for example, (...) where the client and the therapist took turns exposing their problems. In my experience, most people who took up that position eventually saw the merits of relatively orthodox psychotherapy, and many have trained in conventional psychodynamic psychotherapy. I asked my partner, who is also a psychoanalytic psychotherapist, what the term power conjured up for her and got an uncharacteristically sharp response. She said, ‘I hate that word. It’s used by humanistic therapists who are afraid of authority, difference and knowledge and want us all to be the same. It’s like saying colour doesn’t matter. They confuse the abuse of power with the use of power. They assume that all exercise of power is abusive.’. (shrink)

IN THIS PAPER I RESPOND TO SEVERAL OBJECTIONS THAT HAVE BEEN MOUNTED TO MY THEORY OF THE MIRACULOUS. IN PARTICULAR I ARGUE THAT ON MY THEORY A MIRACLE IS DECIDEDLY NOT AN EVENT WHICH IS NATURALLY EXPLICABLE FOR "QUA" MIRACLE AN EVENT IS ONLY EXPLICABLE BY REFERENCE TO THE ACTIVITY OF A NON-NATURAL AGENT’S ALTERING THE SURROUNDING CONDITIONS IN VIRTUE OF HIS ACTIVITY IN THE WORLD.

Janna Lea Thompson, one of Australia’s most distinguished philosophers, died on 24 June 2022, only a few months after being diagnosed with multiple brain tumours. She was, fortunately, largely free...

In this essay I contrast Freud’s account of mourning in Mourning and Melancholia to that of Merleau-Ponty in Phenomenology of Perception. In suggesting a somatic as well as a psychic response, Merleau-Ponty, I argue, more accurately accounts for the ways in which we experience loss and why, contrary to Freud’s suggestion, mourning’s work is never completed.

Both theoretical and empirical work in a variety of disciplines has resulted in a recent turn away from Cartesian and Meadian anthropocentrism in the direction of a radical reconsideration of nonhuman animal mind and agency. Central to sociology’s role in envisioning a repopulated social world is the analysis of nonhuman-human social interaction. Because all social action is predicated on certain assumptions regarding the minds of others, a theory of intersubjectivity must be at the core of any such project. It is (...) argued here that the key elements employed in Alfred Schutz’s conceptualization of intersubjectivity among humans are also demonstrated in the routine communicative projects of humans and their companion animals. After presenting a Schutzian theory of intersubjectivity, this article analyzes, from an ethnographic perspective, elements of the everyday lifeworld Rocky—a deaf, paraplegic cat—cohabits with the author and other family members. Through that analysis, the paper demonstrates that the dynamics of everyday interactions through which Rocky actively participates in the creation of meaning and the achievement of understanding is highly consistent with Schutz’s theory of human intersubjectivity. (shrink)

Page's “localist” code, a population code with occasional, maximally firing elements, does not seem to us usefully or testably different from sparse population coding. Some of the evidence adduced by Page for his proposal is not actually evidence for it, and coding by maximal firing is challenged by lower firing observed in neuronal responses to natural stimuli.

Paternalism has generally been thought of as forcible or coercive interference with a person's liberty of action which is justified because it will prevent harm to that person's welfare interests or the like. Opposition to paternalistic interference with adults, whether it involves the intervention of the state or another adult individual, has usually been based on a concern to preserve human autonomy or self-determination. More strictly it is opposition to so-called ‘strong’ paternalism - interventions to protect or benefit a person (...) despite the person's informed voluntary consent to the contrary- which has been grounded on such a commitment to self-determination. ‘Weak’ paternalism involves interference where there is a defect in the decision-making capacities of the person interfered with. It is claimed to be justifiable insofar asconsentto the interference would be forthcoming were these capacities restored. (shrink)

Paternalism has generally been thought of as forcible or coercive interference with a person's liberty of action which is justified because it will prevent harm to that person's welfare interests or the like. Opposition to paternalistic interference with adults, whether it involves the intervention of the state or another adult individual, has usually been based on a concern to preserve human autonomy or self-determination. More strictly it is opposition to so-called ‘strong’ paternalism - interventions to protect or benefit a person (...) despite the person's informed voluntary consent to the contrary- which has been grounded on such a commitment to self-determination. ‘Weak’ paternalism involves interference where there is a defect in the decision-making capacities of the person interfered with. It is claimed to be justifiable insofar asconsentto the interference would be forthcoming were these capacities restored. (shrink)

In this collection of closely interrelated essays, Robert Young emphasizes the scope of the nineteenth-century debate on 'man's place in nature' at the same time as he engages with the approaches of scholars who write about it. He is critical of the separation of the writing of history from writing about history, historiography, and of the separation of history from politics and ideology, then or now. Dr Young challenges fellow historians for reimposing the very disciplinary boundaries that (...) the nineteenth-century debate showed were in the service of ideological forces in that culture. Rather, he proposes that the full weight of the contending forces should be made apparent and debated openly so that neither nineteenth-century nor contemporary issues about the role of science in culture should be treated in a narrow perspective. (shrink)

The orientation and leadership of the revolutionary “renewal of the German mind,” whose witnesses and participants we are, point in two directions. On, after seizing power, would like to talk the mind into helping out with internal development and promises it a golden age if it joins up; indeed it even offers it the prospect of a certain voice in decision making. The other direction, on the contrary, attests its mistrust of the intellect by declaring that the revolutionary process will (...) continue indefinitely, and has room for the mind in its task; or it might also assure the intellect that it is not needed at all because a new mind has already turned up, and that the old one might as well jump into the fire and either burn to ashes or purify itself into its elements. What has happened up to the moment these words are being written leaves no doubt that the second direction is on the march, the first its musical accompaniment. Nor can it be otherwise than that a Movement [National Socialism] that has manifested itself so powerfully demands above all that the intellect complete assimilate and subordinate itself to the Movement. But then again, it is possible that the intellect cannot do this without renouncing itself. Surely there must be some sort of boundary here, since nothing happens that is not contingent; so it is a good test for the intellect that today it has everywhere been saddled with a kind of kangaroo-court mentality that judges it not according to its own laws, but according to the law of the Movement. Robert Musil made a decisive contribution to twentieth-century European literature. Among his works available in English are Young Törless, Posthumous Papers of a Living Author, and The Man Without Qualities. Burton Pike is professor of comparative literature at the Graduate School of the City University of New York. With Sophie Wilkins, he has edited and translated a new edition of Musil’s novel The Man without Qualities, available in 199. He is the author of Robert Musil: An Introduction to His Work and The Image of the City in Modern Literature . David S. Luft teaches modern European intellectual history at the University of California, San Diego. He is the author of Robert Musil and the Crisis of European Culture, 1880-1912. (shrink)

In this Critical Notice of Emily Jackson and John Keown’s Debating Euthanasia , the respective lines of argument put forward by each contributor are set out and the key debating points identified. Particular consideration is given to the points each contributor makes concerning the sanctity of human life and whether slippery slopes leading from voluntary medically assisted dying to non-voluntary euthanasia would be established if voluntary medically assisted dying were to be legalised. Finally, consideration is given to the positions adopted (...) by the contributors in relation to the legalisation of voluntary medically assisted dying. (shrink)

Recent structural innovations in global commerce present difficult challenges for legacy understandings of responsibility. The rise of outsourcing, sub-contracting, and mobile app-based platforms have dramatically restructured relationships between and among economic actors. Though not entirely new, the remarkable rise in the prevalence of these “not-quite-arm’s-length” relationships present difficulties for conceptions of responsibility based on interrogating the past for specifiable actions by blameworthy actors. Iris Marion Young invites investigation of a “social connection model of responsibility” (SCMR) that is, in many (...) ways, better suited to this new commercial reality. Scholars working to understand corporate responsibility have invoked Young’s model to some good effect, though often superficially and uncritically. In this paper, we look closely at Young’s social connection model and its potential for helping us understand corporate responsibility in a radically networked world. (shrink)

In a recent article, Iris Marion Young raises several challenges to deliberative democracy on behalf of political activists. In this paper, the author defends a version of deliberative democracy against the activist challenges raised by Young and devises challenges to activism on behalf of the deliberative democrat. Key Words: activism • deliberative democracy • Discourse • Ideology • public sphere • I. M. Young.

ABSTRACT We argue that in societies like our own the prevailing view that parents have both special responsibilities for and special rights over their children fails to give a proper understanding of the autonomy both of parents and of children. It is our claim that there is a logical priority of the separable interests of a child over the autonomy of its parents in the fulfilment of their special responsibilities for and the exercise of their special rights over their children. (...) However, we believe that in acknowledging the child as a distinct locus of interests appropriate weight can still be given to parental autonomy. In particular, since raising a child is a long‐term commitment which plays a central role in the life‐plans of many adults it will be a legitimate exercise of an adult's autonomy strongly to influence the future of any children involved in such a plan. Such influence will be quite separate from paternalistic concern for those children. But the logical priority of the child's interests will at the same time show why parents are not entitled to behave proprietorially toward their children, even when paternalistic concern is called for. (shrink)

Children's cooperation with peers undergoes substantial developmental changes between 3 and 10 years of age. Here we stipulate that young children's initial fearfulness of peers' behaviour develops into older children's fearfulness of peers' evaluations of their own behaviour. Cooperation may constitute an adaptive environment in which the expressions of fear and self-conscious emotions regulate the quality of children's peer relationships.

This review essay discusses two recent attempts to reform the framework in which issues of international and global justice are discussed: Iris Marion Young's ?social connection' model and the practice-dependent approach, here exemplified by Ayelet Banai, Miriam Ronzoni and Christian Schemmel's edited collection. I argue that while Young's model may fit some issues of international or global justice, it misconceives the problems that many of them pose. Indeed, its difficulties point precisely in the direction of practice dependence as (...) it is presented by Banai et al. I go on to discuss what seem to be the strengths of that method, and particularly Banai et al.'s defence of it against the common claim that it is biased towards the status quo. I also discuss Andrea Sangiovanni and Kate MacDonald's contributions to the collection. (shrink)

In 1763, the young James Boswell left Great Britain for a 'Grand Tour' of the Continent. The tour was a tradition among British and Scottish youths; by visiting the great historical sites, especially those of Roman and Greek antiquity, they would complete the studies they had begun at universities back home. Boswell's tour, however, was different: he was less concerned with the ruins of the past than the thinkers of the present. In particular, he was eager to question the (...) leading figures of the Enlightenment on matters of faith and God--of particular importance to Boswell, who had been raised in the dour and dire atmosphere of the Church of Scotland. In his remarkable conversations with figures like Voltaire, Rousseau, and Hume, we see a man struggling with the claims of reason and needs of faith--a struggle that remains very much our own 250 years later. (shrink)

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

The purpose of this dissertation is to provide a historically and philosophically adequate interpretation of the earliest of Martin Heidegger's writings, works spanning his student years of 1910--1919. Heidegger conceived his project during his student years as a vital retrieval of what he understood as a unique medieval spirituality and religiosity integrated both with the conceptual rigor of a truly new and progressive Scholasticism that had replaced its reliance on the Aristotelian doctrine of logic and categories with the more flexible (...) theory of logic and sciences of the neo-Kantian and phenomenological movements. This Heideggerian neo-Scholasticism would, he believed, be able to address and to incorporate the constant revolutions in thought of the contemporary sciences. Seen against the background of the intellectual situation of the first two decades of the twentieth century, these works appear as an innovative, albeit flawed, synthesis of medieval scholasticism with current trends in epistemology and logic and as tailored to meet at once the needs of both academic philosophy and Roman Catholic theology. While some commentators and biographers have explored particular issues contributing to Heidegger's thought and goals at this time, no single source has brought together a full appreciation of the complexities his philosophical position within his contemporary situation. This dissertation hopes to be a first step in rectifying this deficiency in the scholarship on the young Heidegger's student years by providing a historically rich and nuanced reading of the complexity of the neo-Scholastic movement at the turn of the twentieth century, the problems that beset German academic philosophy even as the practitioners of the neoKantian and phenomenological schools vied for prominence within the field, and the social difficulties lying before a Catholic seeking entrance into the ranks of the university. These elements must be addressed as a necessary precondition for a full appreciation of Heidegger's early ambitions and the works that grew out of his personal project. (shrink)

Some scholars have responded to the increasingly widespread concerns about Immanuel Kant’s racism by promoting his cosmopolitanism as if the two were self-evidently incompatible, but his particular form of cosmopolitanism has its own history of difficulties when it comes to both racism and anti-Judaism. These concerns can be grounded historically if one links his 1784 essay on history with his account of cosmopolitanism in his 1793 lectures on the metaphysics of morals, where he criticized Jews for failing to embrace cosmopolitanism. (...) Kant’s attack on the Jews was in line with Johann Gottlieb Fichte’s attack on them that had provoked Saul Ascher, a young Jewish Kantian, to accuse Fichte of inventing a new form of anti-Judaism. In this essay I reaffirm my rejection of the widespread claim that Kant toward the end of his life abandoned his belief in a racial hierarchy. I also demonstrate that he used the idea of cosmopolitanism as a tool not only against non-whites, but also against Jews. Kant’s cosmopolitanism should not be presented as the corrective to his racism, but as a new and dangerous addition to his earlier focus on inferiority. (shrink)

In the year 1894, Husserl had not been already contaminated by Bolzano’s realism. It was then that he conceived a theory of assumptions in order to “save an existence” for mathematical objects. Here we would like to explore this theory and show in what way it represented a convincing alternative to realistic ontology and its counterpart: the correspondence theory of truth. However, as soon as he designed it, Husserl shoved away all the implications for his theory of assumptions, and merely (...) abandoned it. We would also like to consider the wrong reasons for this renouncement, which undoubtedly have to do with the dichotomy between signification and perception in his elaboration of phenomenology. (shrink)